Monocyte glycolysis determines CD8(+) T cell functionality in human Chagas disease

Chagas disease is a lifelong pathology resulting from Trypanosoma cruzi infection. It represents one of the most frequent causes of heart failure and sudden death in Latin America. Herein, we provide evidence that aerobic glycolytic pathway activation in monocytes drives nitric oxide (NO) production...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Sanmarco, Liliana María, Eberhardt, Natalia, Bergero, Gastón, Quebrada Palacio, Luz Piedad, Adami, Pamela Martino, Visconti, Laura Marina, Minguez, Ángel Ramón, Hernández-Vasquez, Yolanda, Silva, Eugenio Antonio Carrera, Morelli, Laura, Postan, Miriam, Aoki, Maria Pilar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795286/
https://ncbi.nlm.nih.gov/pubmed/31479429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123490
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