Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins

CRISPR-Cas systems are bacterial adaptive immune pathways that have revolutionized biotechnology and biomedical applications. Despite the potential for human therapeutic development, there are many hurdles that must be overcome before its use in clinical settings. Some clinical safety concerns arise...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:RNA
Main Authors: Lee, Jooyoung, Mou, Haiwei, Ibraheim, Raed, Liang, Shun-Qing, Liu, Pengpeng, Xue, Wen, Sontheimer, Erik J.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2019
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795140/
https://ncbi.nlm.nih.gov/pubmed/31439808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.071704.119
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