Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance

The immune system in tolerance maintains cell diversity without responding to self-antigens. Foxp3-expressing CD25(+)CD4(+) regulatory T cells (Tregs) inhibit T-cell activation through various molecular mechanisms. However, several key questions are still not resolved, including how Tregs control th...

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Pubblicato in:Int Immunol
Autori principali: Yamaguchi, Tomoyuki, Teraguchi, Shunsuke, Furusawa, Chikara, Machiyama, Hiroaki, Watanabe, Tomonobu M, Fujita, Hideaki, Sakaguchi, Shimon, Yanagida, Toshio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6794947/
https://ncbi.nlm.nih.gov/pubmed/31131864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxz043
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