Atorvastatin Exerts Antileukemia Activity via Inhibiting Mevalonate-YAP Axis in K562 and HL60 Cells

Novel therapeutic strategies are still urgently expected for leukemia despite undisputed success of various targeted therapeutics. The antileukemia activity of Atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on human leukemia cells was investigated. Atorvastatin...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Zhang, Lei, Chen, Ting, Dou, Yonghai, Zhang, Shaolu, Liu, Hongyan, Khishignyam, Tungalagtamir, Li, Xiaofei, Zuo, Duo, Zhang, Zhe, Jin, Meihua, Wang, Ran, Qiu, Yuling, Zhong, YuXu, Kong, Dexin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6794561/
https://ncbi.nlm.nih.gov/pubmed/31649888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01032
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