Removal of N-linked glycosylation enhances PD-L1 detection and predicts anti-PD-1/PD-L1 therapeutic efficacy

Reactivation of T cell immunity by PD-1/PD-L1 immune checkpoint blockade has been shown to be a promising cancer therapeutic strategy. However, PD-L1 immunohistochemical readout is inconsistent with patient response, which presents a clinical challenge to stratify patients. Because PD-L1 is heavily...

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Veröffentlicht in:Cancer Cell
Hauptverfasser: Lee, Heng-Huan, Wang, Ying-Nai, Xia, Weiya, Chen, Chia-Hung, Rau, Kun-Ming, Ye, Leiguang, Wei, Yongkun, Chou, Chao-Kai, Wang, Shao-Chun, Yan, Meisi, Tu, Chih-Yen, Hsia, Te-Chun, Chiang, Shu-Fen, Chao, K.S. Clifford, Wistuba, Ignacio I., Hsu, Jennifer L., Hortobagyi, Gabriel N., Hung, Mien-Chie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793936/
https://ncbi.nlm.nih.gov/pubmed/31327656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.06.008
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