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Different Mechanisms Mediate Development and Expression of Tolerance and Dependence for Peripheral μ-Opioid Antinociception in Rat

The μ-opioid [d-Ala(2),N-Me-Phe(4),Gly-ol(5)]-enkephalin (DAMGO) exerts a peripheral antinociceptive effect against prostaglandin E(2) (PGE(2))-induced mechanical hyperalgesia in the hindpaw of the rat. Tolerance and dependence develop to this effect. We have shown previously that tolerance and depe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Aley, Kochuvelikakam O., Levine, Jon D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 1997
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793920/
https://ncbi.nlm.nih.gov/pubmed/9315920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-20-08018.1997
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