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Different Mechanisms Mediate Development and Expression of Tolerance and Dependence for Peripheral μ-Opioid Antinociception in Rat
The μ-opioid [d-Ala(2),N-Me-Phe(4),Gly-ol(5)]-enkephalin (DAMGO) exerts a peripheral antinociceptive effect against prostaglandin E(2) (PGE(2))-induced mechanical hyperalgesia in the hindpaw of the rat. Tolerance and dependence develop to this effect. We have shown previously that tolerance and depe...
Shranjeno v:
| izdano v: | J Neurosci |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Society for Neuroscience
1997
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6793920/ https://ncbi.nlm.nih.gov/pubmed/9315920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-20-08018.1997 |
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