Protease Inhibitor Coinfusion with Amyloid β-Protein Results in Enhanced Deposition and Toxicity in Rat Brain

Amyloid β-protein, Aβ, is normally produced in brain and is cleared by unknown mechanisms. In Alzheimer’s disease (AD), Aβ accumulates in plaque-like deposits and is implicated genetically in neurodegeneration. Here we investigate mechanisms for Aβ degradation and Aβ toxicity in vivo, focusing on th...

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Publicado no:J Neurosci
Main Authors: Frautschy, Sally A., Horn, David L., Sigel, Jason J., Harris-White, Marni E., Mendoza, John J., Yang, Fusheng, Saido, T. C., Cole, Gregory M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792856/
https://ncbi.nlm.nih.gov/pubmed/9763475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-20-08311.1998
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