Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation

Primary cultures of rat embryonic motor neurons deprived of brain-derived neurotrophic factor (BDNF) induce neuronal nitric oxide synthase (NOS) within 18 hr. Subsequently, >60% of the neurons undergo apoptosis between 18 and 24 hr after plating. Nitro-l-arginine and nitro-l-arginine methyl ester...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Estévez, Alvaro G., Spear, Nathan, Manuel, S. Machelle, Radi, Rafael, Henderson, Christopher E., Barbeito, Luis, Beckman, Joseph S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792767/
https://ncbi.nlm.nih.gov/pubmed/9437014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-03-00923.1998
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