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Spectrum of TERT promoter mutations and mechanisms of activation in thyroid cancer
BACKGROUND: Reactivation of telomerase reverse transcriptase (TERT) is an important event in cancer. Two hotspot mutations in the TERT promoter region, c.‐124C > T (C228T) and c.‐146C > T (C250T), occur in various cancer types including thyroid cancer. They generate de novo binding sites for E...
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| Pubblicato in: | Cancer Med |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6792496/ https://ncbi.nlm.nih.gov/pubmed/31408918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.2467 |
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