Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis

[Image: see text] In this study, a series of 49 five-membered heterocyclic compounds containing either a pyridine- or a pyrrole-type nitrogen were synthesized and tested against Mycobacterium tuberculosis. Among them, only the 1,3,5-trisubstituted pyrazoles 5–49 exhibited minimum inhibitory concentr...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Poce, Giovanna, Consalvi, Sara, Venditti, Giulia, Alfonso, Salvatore, Desideri, Nicoletta, Fernandez-Menendez, Raquel, Bates, Robert H., Ballell, Lluis, Barros Aguirre, David, Rullas, Joaquin, De Logu, Alessandro, Gardner, Michelle, Ioerger, Thomas R., Rubin, Eric J., Biava, Mariangela
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792160/
https://ncbi.nlm.nih.gov/pubmed/31620228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00204
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