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Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
Sensitive and specific DNA hybridization is essential for nucleic acid chemistry. Competitive composition of probe and blocker has been the most adopted probe design for its relatively high sensitivity and specificity. However, the sensitivity and specificity were inversely correlated over the lengt...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6791858/ https://ncbi.nlm.nih.gov/pubmed/31611572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12593-9 |
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