Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization

Sensitive and specific DNA hybridization is essential for nucleic acid chemistry. Competitive composition of probe and blocker has been the most adopted probe design for its relatively high sensitivity and specificity. However, the sensitivity and specificity were inversely correlated over the lengt...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Chen, Xin, Liu, Na, Liu, Liquan, Chen, Wei, Chen, Na, Lin, Meng, Xu, Jiaju, Zhou, Xing, Wang, Hongbo, Zhao, Meiping, Xiao, Xianjin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791858/
https://ncbi.nlm.nih.gov/pubmed/31611572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12593-9
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