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Mechanisms of failure of chimeric antigen receptor T-cell therapy

Although chimeric antigen receptor T (CART)-cell therapy is best recognized for its antitumor effect in relapsed/refractory B-cell hematological cancers, it is still associated with a high relapse rate. RECENT FINDINGS: We firstly analyzed internal immunological and genetic reasons of CD19+ relapse...

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Bibliographic Details
Published in:Curr Opin Hematol
Main Authors: Li, Xiaoqing, Chen, Weihong
Format: Artigo
Language:Inglês
Published: Lippincott Williams And Wilkins 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791516/
https://ncbi.nlm.nih.gov/pubmed/31577606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MOH.0000000000000548
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