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Steering CAR T cells to distinguish friend from foe
CD19-specific chimeric antigen receptor (CAR)(+) T cells have demonstrated clinical efficacy and long-lasting remissions, concomitant with tolerable normal B-cell aplasia. However, many tumor-associated antigens (TAAs) are expressed on normal tissues, the destruction of which would lead to intolerab...
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| Publicado en: | Oncoimmunology |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6791456/ https://ncbi.nlm.nih.gov/pubmed/31646067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1271857 |
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