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Steering CAR T cells to distinguish friend from foe

CD19-specific chimeric antigen receptor (CAR)(+) T cells have demonstrated clinical efficacy and long-lasting remissions, concomitant with tolerable normal B-cell aplasia. However, many tumor-associated antigens (TAAs) are expressed on normal tissues, the destruction of which would lead to intolerab...

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書目詳細資料
發表在:Oncoimmunology
Main Authors: Caruso, Hillary G., Heimberger, Amy B., Cooper, Laurence J. N.
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2018
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791456/
https://ncbi.nlm.nih.gov/pubmed/31646067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1271857
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