MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions

scRNA-seq profiles each represent a highly partial sample of mRNA molecules from a unique cell that can never be resampled, and robust analysis must separate the sampling effect from biological variance. We describe a methodology for partitioning scRNA-seq datasets into metacells: disjoint and homog...

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Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: Baran, Yael, Bercovich, Akhiad, Sebe-Pedros, Arnau, Lubling, Yaniv, Giladi, Amir, Chomsky, Elad, Meir, Zohar, Hoichman, Michael, Lifshitz, Aviezer, Tanay, Amos
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790056/
https://ncbi.nlm.nih.gov/pubmed/31604482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1812-2
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