Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST

Streptomycetes serve as major producers of various pharmacologically and industrially important natural products. Although CRISPR-Cas9 systems have been developed for more robust genetic manipulations, concerns of genome instability caused by the DNA double-strand breaks (DSBs) and the toxicity of C...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tong, Yaojun, Whitford, Christopher M., Robertsen, Helene L., Blin, Kai, Jørgensen, Tue S., Klitgaard, Andreas K., Gren, Tetiana, Jiang, Xinglin, Weber, Tilmann, Lee, Sang Yup
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789908/
https://ncbi.nlm.nih.gov/pubmed/31548381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913493116
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