SerpinB1 controls encephalitogenic T helper cells in neuroinflammation

SerpinB1, a protease inhibitor and neutrophil survival factor, was recently linked with IL-17–expressing T cells. Here, we show that serpinB1 (Sb1) is dramatically induced in a subset of effector CD4 cells in experimental autoimmune encephalomyelitis (EAE). Despite normal T cell priming, Sb1(−/−) mi...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Hou, Lifei, Rao, Deepak A., Yuki, Koichi, Cooley, Jessica, Henderson, Lauren A., Jonsson, A. Helena, Kaiserman, Dion, Gorman, Mark P., Nigrovic, Peter A., Bird, Phillip I., Becher, Burkhard, Remold-O’Donnell, Eileen
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789640/
https://ncbi.nlm.nih.gov/pubmed/31548399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905762116
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