Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge

The development of universal influenza vaccines has been a priority for more than 20 years. We conducted a preclinical study in ferrets of two sets of live attenuated influenza vaccines (LAIVs) expressing chimeric hemagglutinin (cHA). These vaccines contained the HA stalk domain from H1N1pdm09 virus...

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Detalhes bibliográficos
Publicado no:Vaccines (Basel)
Main Authors: Isakova-Sivak, Irina, Matyushenko, Victoria, Kotomina, Tatiana, Kiseleva, Irina, Krutikova, Elena, Donina, Svetlana, Rekstin, Andrey, Larionova, Natalia, Mezhenskaya, Daria, Sivak, Konstantin, Muzhikyan, Arman, Katelnikova, Anastasia, Rudenko, Larisa
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789596/
https://ncbi.nlm.nih.gov/pubmed/31288422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines7030061
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