BRD4 degrader ARV-825 produces long-lasting loss of BRD4 protein and exhibits potent efficacy against cholangiocarcinoma cells

BRD4, a member of the bromodomain and extraterminal domain (BET) family and an important epigenetic reader, has emerged as an attractive oncology target. Cholangiocarcinoma is a lethal neoplasm without approved targeted therapies. BET bromodomain inhibitors have shown promising effects in certain ca...

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Detalhes bibliográficos
Publicado no:Am J Transl Res
Main Authors: Lu, Qin, Ding, Xiwei, Huang, Tianlu, Zhang, Shu, Li, Yang, Xu, Lei, Chen, Gang, Ying, Yuyao, Wang, Yun, Feng, Zhenqing, Wang, Lei, Zou, Xiaoping
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789278/
https://ncbi.nlm.nih.gov/pubmed/31632543
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