Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

Prostate is the most frequent cancer in men. Prostate cancer progression is driven by androgen steroid hormones, and delayed by androgen deprivation therapy (ADT). Androgens control transcription by stimulating androgen receptor (AR) activity, yet also control pre-mRNA splicing through less clear me...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Munkley, Jennifer, Li, Ling, Krishnan, S R Gokul, Hysenaj, Gerald, Scott, Emma, Dalgliesh, Caroline, Oo, Htoo Zarni, Maia, Teresa Mendes, Cheung, Kathleen, Ehrmann, Ingrid, Livermore, Karen E, Zielinska, Hanna, Thompson, Oliver, Knight, Bridget, McCullagh, Paul, McGrath, John, Crundwell, Malcolm, Harries, Lorna W, Daugaard, Mads, Cockell, Simon, Barbosa-Morais, Nuno L, Oltean, Sebastian, Elliott, David J
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Chromosomes and Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788855/
https://ncbi.nlm.nih.gov/pubmed/31478829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47678
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