Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha

Secreted amyloid precursor protein-alpha (sAPPα) has growth factor-like properties and can modulate long-term potentiation (LTP) and memory. Here, we demonstrate that exposure to sAPPα converts short-lasting LTP into protein-synthesis-dependent late LTP in hippocampal slices from male rats. sAPPβ ha...

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Vydáno v:J Neurosci
Hlavní autoři: Mockett, Bruce G., Guévremont, Diane, Elder, Megan K., Parfitt, Karen D., Peppercorn, Katie, Morrissey, Jodi, Singh, Anurag, Hintz, Timothy J., Kochen, Lisa, tom Dieck, Susanne, Schuman, Erin, Tate, Warren P., Williams, Joanna M., Abraham, Wickliffe C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788824/
https://ncbi.nlm.nih.gov/pubmed/30804097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1826-18.2019
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