Glutamate Receptor Trafficking and Protein Synthesis Mediate the Facilitation of LTP by Secreted Amyloid Precursor Protein-Alpha

Secreted amyloid precursor protein-alpha (sAPPα) has growth factor-like properties and can modulate long-term potentiation (LTP) and memory. Here, we demonstrate that exposure to sAPPα converts short-lasting LTP into protein-synthesis-dependent late LTP in hippocampal slices from male rats. sAPPβ ha...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Mockett, Bruce G., Guévremont, Diane, Elder, Megan K., Parfitt, Karen D., Peppercorn, Katie, Morrissey, Jodi, Singh, Anurag, Hintz, Timothy J., Kochen, Lisa, tom Dieck, Susanne, Schuman, Erin, Tate, Warren P., Williams, Joanna M., Abraham, Wickliffe C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788824/
https://ncbi.nlm.nih.gov/pubmed/30804097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1826-18.2019
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