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Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients
Transdermal fentanyl is widely used to control pain in cancer patients. The high pharmacokinetic variability of fentanyl is assumed to be due to cytochrome P450 3A-mediated (CYP3A) N-dealkylation to norfentanyl in humans. However, recently published clinical studies question the importance of the de...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6786992/ https://ncbi.nlm.nih.gov/pubmed/31601999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51279-6 |
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