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Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation
Lysosomes are the terminal organelles of the autophagic-endocytic pathway and play a key role in the degradation of autophagic contents. We previously reported that a natural compound oblongifolin C (OC) increased the number of autophagosomes and impaired the degradation of P62, most likely via supp...
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| Udgivet i: | Acta Pharmacol Sin |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6786433/ https://ncbi.nlm.nih.gov/pubmed/30333555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-018-0167-7 |
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