Integrating yeast chemical genomics and mammalian cell pathway analysis

Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae. Here, we use yeast as a surrogate system for studying compounds that are active against metazoan targets. Large-scale chemical-genetic profiling of thousands of...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Zhou, Fu-lai, Li, Sheena C, Zhu, Yue, Guo, Wan-jing, Shao, Li-jun, Nelson, Justin, Simpkins, Scott, Yang, De-hua, Liu, Qing, Yashiroda, Yoko, Xu, Jin-biao, Fan, Yao-yue, Yue, Jian-min, Yoshida, Minoru, Xia, Tian, Myers, Chad L, Boone, Charles, Wang, Ming-wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6786357/
https://ncbi.nlm.nih.gov/pubmed/31138898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0231-y
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