Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions

Chemical-genetic interactions–observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes–contain rich functional information linking compounds to their cellular modes of action. To systematically identify these interactions, an array of mutants is challenged wi...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Simpkins, Scott W., Nelson, Justin, Deshpande, Raamesh, Li, Sheena C., Piotrowski, Jeff S., Wilson, Erin H., Gebre, Abraham A., Safizadeh, Hamid, Okamoto, Reika, Yoshimura, Mami, Costanzo, Michael, Yashiroda, Yoko, Ohya, Yoshikazu, Osada, Hiroyuki, Yoshida, Minoru, Boone, Charles, Myers, Chad L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226211/
https://ncbi.nlm.nih.gov/pubmed/30376562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006532
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