Elevated Endogenous SDHA Drives Pathological Metabolism in Highly Metastatic Uveal Melanoma

PURPOSE: Metastatic uveal melanoma (UM) has a very poor prognosis and no effective therapy. Despite remarkable advances in treatment of cutaneous melanoma, UM remains recalcitrant to chemotherapy, small-molecule kinase inhibitors, and immune-based therapy. METHODS: We assessed two sets of oxidative...

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Detalles Bibliográficos
Publicado en:Invest Ophthalmol Vis Sci
Autores principales: Chattopadhyay, Chandrani, Oba, Junna, Roszik, Jason, Marszalek, Joseph R., Chen, Ken, Qi, Yuan, Eterovic, Karina, Robertson, A. Gordon, Burks, Jared K., McCannel, Tara A., Grimm, Elizabeth A., Woodman, Scott E.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785781/
https://ncbi.nlm.nih.gov/pubmed/31596927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.19-28082
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