Senescent HUVECs-secreted exosomes trigger endothelial barrier dysfunction in young endothelial cells

Accumulation of senescent endothelial cells can cause endothelium dysfunction which eventually leads to age-related vascular disorders. The senescent-associated secretory phenotype (SASP) cells secrete a plethora of soluble factors that negatively influence the surrounding tissue microenvironment. T...

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Bibliografiske detaljer
Udgivet i:EXCLI J
Main Authors: Wong, Pooi-Fong, Tong, Kind-Leng, Jamal, Juliana, Khor, Eng-Soon, Lai, Siew-Li, Mustafa, Mohd Rais
Format: Artigo
Sprog:Inglês
Udgivet: Leibniz Research Centre for Working Environment and Human Factors 2019
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785768/
https://ncbi.nlm.nih.gov/pubmed/31611757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2019-1505
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