Epigenetic initiation of the T(H)17 differentiation program is promoted by Cxxc finger protein 1

IL-6/STAT3 signaling is known to initiate the T(H)17 differentiation program, but the upstream regulatory mechanisms remain minimally explored. Here, we show that Cxxc finger protein 1 (Cxxc1) promoted the generation of T(H)17 cells as an epigenetic regulator and prevented their differentiation into...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Lin, Feng, Meng, Xiaoyu, Guo, Yixin, Cao, Wenqiang, Liu, Wanlu, Xia, Qiming, Hui, Zhaoyuan, Chen, Jian, Hong, Shenghui, Zhang, Xuliang, Wu, Chuan, Wang, Di, Wang, Jianli, Lu, Linrong, Qian, Wenbin, Wei, Lai, Wang, Lie
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785255/
https://ncbi.nlm.nih.gov/pubmed/31633019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax1608
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