Occupancy of dopamine D(2) and D(3) receptors by a novel D3 partial agonist BP1.4979: a [(11)C]-(+)-PHNO PET study in humans

There has been considerable interest in the development of dopamine D3 receptor (DRD(3)) partial agonists and antagonists for the treatment of substance use disorders. Pre-clinical evidence overwhelmingly supports the use of these drugs, but translation to humans has remained elusive due to the lack...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Di Ciano, Patricia, Mansouri, Esmaeil, Tong, Junchao, Wilson, Alan A., Houle, Sylvain, Boileau, Isabelle, Duvauchelle, Thierry, Robert, Philippe, Schwartz, Jean Charles, Le Foll, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785153/
https://ncbi.nlm.nih.gov/pubmed/30659274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0285-4
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