Cerebral Microvascular Obstruction by Fibrin is Associated with Upregulation of PAI-1 Acutely after Onset of Focal Embolic Ischemia in Rats

The mechanisms underlying cerebral microvascular perfusion deficit resulting from occlusion of the middle cerebral artery (MCA) require elucidation. We, therefore, tested the hypothesis that intravascular fibrin deposition in situ directly obstructs cerebral microcirculation and that local changes i...

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Pubblicato in:J Neurosci
Autori principali: Zhang, Zheng Gang, Chopp, Michael, Goussev, Anton, Lu, Dunyue, Morris, Daniel, Tsang, Wayne, Powers, Cecylia, Ho, Khang-Loon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 1999
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ARTICLE
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784928/
https://ncbi.nlm.nih.gov/pubmed/10594071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-24-10898.1999
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