Cerebral Microvascular Obstruction by Fibrin is Associated with Upregulation of PAI-1 Acutely after Onset of Focal Embolic Ischemia in Rats

The mechanisms underlying cerebral microvascular perfusion deficit resulting from occlusion of the middle cerebral artery (MCA) require elucidation. We, therefore, tested the hypothesis that intravascular fibrin deposition in situ directly obstructs cerebral microcirculation and that local changes i...

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Publicado en:J Neurosci
Autores principales: Zhang, Zheng Gang, Chopp, Michael, Goussev, Anton, Lu, Dunyue, Morris, Daniel, Tsang, Wayne, Powers, Cecylia, Ho, Khang-Loon
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 1999
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784928/
https://ncbi.nlm.nih.gov/pubmed/10594071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-24-10898.1999
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