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To randomize, or not to randomize, that is the question: using data from prior clinical trials to guide future designs

BACKGROUND: Understanding the value of randomization is critical in designing clinical trials. Here, we introduce a simple and interpretable quantitative method to compare randomized designs versus single-arm designs using indication-specific parameters derived from the literature. We demonstrate th...

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Bibliografski detalji
Izdano u:Neuro Oncol
Glavni autori: Vanderbeek, Alyssa M, Ventz, Steffen, Rahman, Rifaquat, Fell, Geoffrey, Cloughesy, Timothy F, Wen, Patrick Y, Trippa, Lorenzo, Alexander, Brian M
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784282/
https://ncbi.nlm.nih.gov/pubmed/31155679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz097
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