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Integrated Clarification and Purification of Monoclonal Antibodies by Membrane Based Separation of Aqueous Two-Phase Systems

Therapeutic monoclonal antibodies (mAb) are used for the treatment of numerous serious diseases, which have led to an increasing demand over the last decades. Increased cell density and mAb titer of the cultivation broth lead to great challenges for the subsequent clarification and capture operation...

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Detalhes bibliográficos
Publicado no:Antibodies (Basel)
Main Authors: Kruse, Thomas, Schmidt, Axel, Kampmann, Markus, Strube, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784141/
https://ncbi.nlm.nih.gov/pubmed/31544846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib8030040
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