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Optimising low‐dose methotrexate for rheumatoid arthritis—A review
Methotrexate at low doses (5–25 mg/week) is first‐line therapy for rheumatoid arthritis. However, there is inter‐ and intrapatient variability in response, with contribution of variability in concentrations of active polyglutamate metabolites, associated with clinical efficacy and toxicity. Prescrib...
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| Publicado no: | Br J Clin Pharmacol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6783593/ https://ncbi.nlm.nih.gov/pubmed/31276602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14057 |
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