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Doc2b Ca(2+) binding site mutants enhance synaptic release at rest at the expense of sustained synaptic strength

Communication between neurons involves presynaptic neurotransmitter release which can be evoked by action potentials or occur spontaneously as a result of stochastic vesicle fusion. The Ca(2+)-binding double C(2) proteins Doc2a and –b were implicated in spontaneous and asynchronous evoked release, b...

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Publicat a:Sci Rep
Autors principals: Bourgeois-Jaarsma, Quentin, Verhage, Matthijs, Groffen, Alexander J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783474/
https://ncbi.nlm.nih.gov/pubmed/31594980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50684-1
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