T CELL SPECIFIC ADAPTOR PROTEIN REGULATES MITOCHONDRIAL FUNCTION AND CD4(+) T REGULATORY CELL ACTIVITY IN VIVO FOLLOWING TRANSPLANTATION

T cell specific adaptor protein (TSAd, encoded by the SH2D2A gene) is an intracellular molecule that binds Lck to elicit signals that result in cytokine production in CD4(+) Teff cells. Nevertheless, using Sh2d2a knockout mice (TSAd KO), we find that alloimmune CD4(+) Teff responses are fully compet...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Wedel, Johannes, Stack, Maria P., Seto, Tatsuichiro, Sheehan, Matthew M., Flynn, Evelyn A., Stillman, Isaac E., Kong, Sek Won, Liu, Kaifeng, Briscoe, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783373/
https://ncbi.nlm.nih.gov/pubmed/31541025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801604
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