Quiescent cells actively replenish CENP-A nucleosomes to maintain centromere identity and proliferative potential

Centromeres provide a robust model for epigenetic inheritance as they are specified by sequence-independent mechanisms involving the histone H3-variant CENP-A. Prevailing models indicate that the high intrinsic stability of CENP-A nucleosomes maintains centromere identity indefinitely. Here, we demo...

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Publicado en:Dev Cell
Autores principales: Swartz, S. Zachary, McKay, Liliana S., Su, Kuan-Chung, Bury, Leah, Padeganeh, Abbas, Maddox, Paul S., Knouse, Kristin A., Cheeseman, Iain M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783363/
https://ncbi.nlm.nih.gov/pubmed/31422918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.07.016
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