Functionally Antagonistic Interactions between the TrkA and p75 Neurotrophin Receptors Regulate Sympathetic Neuron Growth and Target Innervation

In this report, we provide evidence that NGF and BDNF have functionally antagonistic actions on sympathetic neuron growth and target innervation, with NGF acting via TrkA to promote growth and BDNF via p75NTR to inhibit growth. Specifically, in cultured sympathetic neurons that themselves synthesize...

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Bibliographic Details
Published in:	J Neurosci
Main Authors:	Kohn, Judi, Aloyz, Raquel S., Toma, Jean G., Haak-Frendscho, Mary, Miller, Freda D.
Format:	Artigo
Language:	Inglês
Published:	Society for Neuroscience 1999
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6782315/ https://ncbi.nlm.nih.gov/pubmed/10377349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-13-05393.1999
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Functionally Antagonistic Interactions between the TrkA and p75 Neurotrophin Receptors Regulate Sympathetic Neuron Growth and Target Innervation

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