Functionally Antagonistic Interactions between the TrkA and p75 Neurotrophin Receptors Regulate Sympathetic Neuron Growth and Target Innervation

In this report, we provide evidence that NGF and BDNF have functionally antagonistic actions on sympathetic neuron growth and target innervation, with NGF acting via TrkA to promote growth and BDNF via p75NTR to inhibit growth. Specifically, in cultured sympathetic neurons that themselves synthesize...

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Publicado en:J Neurosci
Autores principales: Kohn, Judi, Aloyz, Raquel S., Toma, Jean G., Haak-Frendscho, Mary, Miller, Freda D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 1999
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782315/
https://ncbi.nlm.nih.gov/pubmed/10377349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-13-05393.1999
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