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Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

Microglial interaction with amyloid fibrils in the brains of Alzheimer’s and prion disease patients results in the inflammatory activation of these cells. We observed that primary microglial cultures and the THP-1 monocytic cell line are stimulated by fibrillar β-amyloid and prion peptides to activa...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Combs, Colin K., Johnson, Derrick E., Cannady, Steve B., Lehman, Timothy M., Landreth, Gary E.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782151/
https://ncbi.nlm.nih.gov/pubmed/9920656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-03-00928.1999
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