Tryptophan and Kynurenine Pathway Metabolites in Animal Models of Retinal and Optic Nerve Damage: Different Dynamics of Changes

Kynurenines, products of tryptophan (TRP) metabolism, display neurotoxic (e.g., 3-hydroxykynurenine; 3-HK), or neuroprotective (e.g., kynurenic acid; KYNA) properties. Imbalance between the enzymes constituting the kynurenine pathway (KP) plays a role in several disease, including neurodegeneration....

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Publicat a:Front Physiol
Autors principals: Fiedorowicz, Michal, Choragiewicz, Tomasz, Thaler, Sebastian, Schuettauf, Frank, Nowakowska, Dominika, Wojtunik, Kamila, Reibaldi, Michele, Avitabile, Teresio, Kocki, Tomasz, Turski, Waldemar A., Kaminska, Agnieszka, Grieb, Pawel, Zrenner, Eberhart, Rejdak, Robert, Toro, Mario Damiano
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Physiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781742/
https://ncbi.nlm.nih.gov/pubmed/31632294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01254
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