Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis

Enhanced carbonyl stress underlies a subset of schizophrenia, but its causal effects remain elusive. Here, we elucidated the molecular mechanism underlying the effects of carbonyl stress in iPS cells in which the gene encoding zinc metalloenzyme glyoxalase I (GLO1), a crucial enzyme for the clearanc...

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Bibliografiske detaljer
Udgivet i:Life Sci Alliance
Main Authors: Toyoshima, Manabu, Jiang, Xuguang, Ogawa, Tadayuki, Ohnishi, Tetsuo, Yoshihara, Shogo, Balan, Shabeesh, Yoshikawa, Takeo, Hirokawa, Nobutaka
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781483/
https://ncbi.nlm.nih.gov/pubmed/31591136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900478
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