Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis

Enhanced carbonyl stress underlies a subset of schizophrenia, but its causal effects remain elusive. Here, we elucidated the molecular mechanism underlying the effects of carbonyl stress in iPS cells in which the gene encoding zinc metalloenzyme glyoxalase I (GLO1), a crucial enzyme for the clearanc...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Toyoshima, Manabu, Jiang, Xuguang, Ogawa, Tadayuki, Ohnishi, Tetsuo, Yoshihara, Shogo, Balan, Shabeesh, Yoshikawa, Takeo, Hirokawa, Nobutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781483/
https://ncbi.nlm.nih.gov/pubmed/31591136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900478
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