Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103(+) dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity

Highly accumulated hyaluronan (HA) not only provides a physiological barrier but also supports an immune-suppressive tumour microenvironment. High-molecular-weight (HMW)-HA inhibits the activation of immune cells and their access into tumour tissues, whereas, low-molecular-weight oligo-HA is known t...

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Vydáno v:J Extracell Vesicles
Hlavní autoři: Hong, Yeonsun, Kim, Yoon Kyoung, Kim, Gi Beom, Nam, Gi-Hoon, Kim, Seong A, Park, Yoon, Yang, Yoosoo, Kim, In-San
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781230/
https://ncbi.nlm.nih.gov/pubmed/31632619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/20013078.2019.1670893
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