Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir

HIV-1 infection requires lifelong therapy with antiretroviral drugs due to the existence of a latent reservoir of transcriptionally inactive integrated proviruses. The goal of HIV-1 cure research is to eliminate or functionally silence this reservoir. To this end, there are numerous ongoing studies...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Gaebler, Christian, Lorenzi, Julio C.C., Oliveira, Thiago Y., Nogueira, Lilian, Ramos, Victor, Lu, Ching-Lan, Pai, Joy A., Mendoza, Pilar, Jankovic, Mila, Caskey, Marina, Nussenzweig, Michel C.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6781006/
https://ncbi.nlm.nih.gov/pubmed/31350309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190896
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