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Diuretic Activity of a Novel Peripherally-Restricted Orally-Active Kappa Opioid Receptor Agonist

Kappa-opioid agonists (KOAs) enhance cardiac performance, as well as reduce infarct size and prevent deleterious cardiac remodeling following myocardial infarction. Additionally, KOAs promote diuresis; however, there has been limited development of KOAs as a class due to the promotion of untoward ce...

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Publicat a:Med Sci (Basel)
Autors principals: Beck, Tyler C., Hapstack, Matthew A., Ghatnekar, Gautam S., Dix, Thomas A.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780874/
https://ncbi.nlm.nih.gov/pubmed/31480425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/medsci7090093
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