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Non-addictive orally-active kappa opioid agonists for the treatment of peripheral pain in rats

Addiction to conventional opioid pain analgesics is a major societal problem that is increasing at an alarming rate. New drugs to combat the effects of opioid abuse are desperately needed. Kappa-opioid agonists are efficacious in peripheral pain models but suffer from centrally-mediated effects. In...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Beck, Tyler C., Reichel, Carmela M., Helke, Kristi L., Bhadsavle, Sanat S., Dix, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696947/
https://ncbi.nlm.nih.gov/pubmed/31103632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2019.05.025
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