Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA

µ-Conotoxin PIIIA, in the sub-picomolar, range inhibits the archetypal bacterial sodium channel NaChBac (NavBh) in a voltage- and use-dependent manner. Peptide µ-conotoxins were first recognized as potent components of the venoms of fish-hunting cone snails that selectively inhibit voltage-gated ske...

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Publicat a:Mar Drugs
Autors principals: Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Korkosh, Vyacheslav S., Huang, Sun, McMaster, Denis, Glavica, Robert, Tikhonov, Denis B., Zhorov, Boris S., French, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780087/
https://ncbi.nlm.nih.gov/pubmed/31470595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17090510
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