Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma

Multiple myeloma (MM) drug resistance highlights a need for alternative therapeutic strategies. In this study, we show that CASIN, a selective inhibitor of cell division cycle 42 (Cdc42) GTPase, inhibited proliferation and survival of melphalan/bortezomib-resistant MM cells more profoundly than that...

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Detalles Bibliográficos
Publicado en:Front Oncol
Main Authors: Nguyen, Phuong, Chakrabarti, Jayati, Li, Yuan, Kalim, Khalid W., Zhang, Mengnan, Zhang, Lin, Zheng, Yi, Guo, Fukun
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779689/
https://ncbi.nlm.nih.gov/pubmed/31632904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00958
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