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HER2 amplification in tumors activates PI3K/Akt signaling independent of HER3

Current evidence suggests that HER2-driven tumorigenesis requires HER3. This is likely due to the unique ability of HER3 to activate PI3K/Akt pathway signaling, which is not directly accessible to HER2. By genetic elimination of HER3 or shRNA knockdown of HER3 in HER2-amplified cancer cells, we find...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Ruiz-Saenz, Ana, Dreyer, Courtney, Campbell, Marcia R, Steri, Veronica, Gulizia, Nate, Moasser, Mark M
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779043/
https://ncbi.nlm.nih.gov/pubmed/29760043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0430
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